DescriptionSAMe is a natural form of bioactive methionine. It is a result of the conversion of methionine by ATP and the enzyme SAMe synthetase. It is used by the body to produce the neurotransmitters dopamine, norepinepherine, and serotonin. It is also used in the production and protection of DNA and RNA, and in the production of phosphatidylcholine, which may be beneficial in keeping cell membranes in a youthful state. SAMe is utilized by almost every cell of the body and that is why it has such a wide variety of benefits.
SAMe is used by the body in the following metabolic pathways, methylation, synthesis of polyamines, and trans-sulphuration. Methylation is involved in protection or transformation of other molecules such as DNA and homocysteine. Synthesis of polyamines results in cell growth, gene expression, neuron regeneration, etc. and trans-sulphuration is the synthesis of L-cysteine, glutathione and other sulfate groups, which are involved in liver support and detoxification.
In Chinese medicine the liver is thought of as the seat of emotion and compromised liver function is thought to be involved in mood. Research has shown SAMe as being of benefit in lowering elevated liver enzymes. It is suspected that SAMe protects synovial cells by reversing glutathione depletion, thereby being beneficial for compromised joint function and degeneration. Studies have shown that during joint degeneration the synovial fluid may contain damaging cytokines (TNF) and free radicals.
In addition, SAMe may protect proteoglycans (protein cells, composed of keratin and chondroitin sulfate) and chondrocytes (cartilage cells, that make proteoglycans and collagen) the components of the spongy tissues between joint called cartilage that breaks down during joint degeneration.*
For optimal metabolism and utilization of SAMe, it should be taken with B6, B12 and folic acid. Therefore we suggest Item no. 72580, HomoCysteine Metabolite Formula or Item no. 73230, TMG (Trimethylglycine).
Hypoallergenic.
Each 2 tablets contain:
SAMe 400 mg
Suggested use: As a dietary supplement, 1 tablet before meals in the morning and one in the afternoon. This may be increased by taking 1 tablet in the morning and 2 tablets in the afternoon, and for some individuals, an additional tablet in the evening. After two weeks, a maximum dose of two tablets in the morning, two in the afternoon, and two in the evening may be taken.
*This statement has not been evaluated by the U.S. Food and Drug administration. The product is not intended to diagnose, treat, cure, or prevent any disease.
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