Natural Training Supplement - 60 caps

DescriptionEndurox Excel (maximum strength formula) -- 1,200 mg standardized extract of ciwujia; Vitamin E (60 IU)/ 2 caplets

Endurox Excel is guaranteed to help you exceed your personal best. Endurox Excel builds endurance, raises the lactate threshold, speeds workout recovery, and increases cardiac efficiency by lowering the heart rate by maintaining the same level of workout intensity. Endurox Excel contains maximum strength Endurox plus vitamin E. Endurox Excel slows the lactic acid buildup that causes muscle fatigue. Vitamin E has been shown to improve workout recovery by preventing the buildup of free radicals associated with muscle damage and soreness.

ENDUROX EXCEL is a dietary supplement that, when taken as part of your training regimen, is proven to enhance workout performance by raising the lactate threshold and increasing cardiac efficiency, build endurance, speed recovery, and increase fat metabolism.* The recommended dose of two caplets contains 1,200 mg of ENDUROX, a standardized extract of the herb ciwujia, and 60 IUs of vitamin E (50% more ciwujia than regular ENDUROX and 200% of the Daily Value for vitamin E).

Over the last decade, researchers in exercise physiology have focused on identifying agents that could improve physical endurance. This research has followed two lines of investigation. One line explored the use of agents that increase strength and muscle mass. The best known of these agents are anabolic steroids, which have been shown to accelerate the rate of recovery following resistance exercise and to increase protein synthesis in muscle tissue. These effects enable an increased training effect to occur, resulting in an increase in muscle strength and an improvement in exercise performance.

Anabolic steroids, however, have a serious downside. They are associated with major side effects which include virilization, disorders of the reproductive systems, psychological abnormalities, and an increased incidence of liver and heart disease. The second line of investigation has focused on fuel utilization during exercise to generate ATP, the energy currency of the muscle cell. During intense exercise, total energy expenditure increases 15- to 25-fold. This increase changes the demands on available fuel supplies, resulting in differing levels of efficacy and work capacity related to the metabolic pathways that are called upon.

Although muscle has the capacity to use the three primary nutrients, protein, carbohydrate, and fat, for fuel, it is the balance of carbohydrate and fat utilization during exercise that largely determines exercise performance and duration. With the exception of extreme intense exercise of short duration, the body uses a combination of carbohydrate and fat for fuel.

At lower exercise intensity and longer duration, fat can become the primary energy source. This in no way minimizes the critical role of carbohydrates. The importance of carbohydrates is underscored by the fact that depletion of the intramuscular stores of carbohydrate is almost always associated with muscular exhaustion. As early as 1939 exercise physiologists showed they could significantly increase exercise endurance by placing subjects on a high-carbohydrate, low-fat diet. This early work laid the foundation for the development of carbohydrate-loading techniques which have been incorporated into the training programs of many serious athletes.

Equally important in defining the relationship between carbohydrate utilization and exercise endurance was the work of Costill et al at the Human Performance Laboratory at Ball State University. These investigators showed that caffeine could improve endurance through a carbohydrate-sparing action. Although these results were impressive, other actions of caffeine, including stimulation of the central nervous and cardiovascular systems as well as a diuretic effect, made it less than ideal as an agent to improve athletic performance.

Much of the work concerning energy utilization during exercise was conducted in the high-performance athlete. However, it is clear that the application of these findings may be extended to benefit any individual who exercises regularly to maintain weight or optimize physical performance.

Pharmacologic Profile of ENDUROX Ciwujia, a natural root grown in the northeast section of China, has been used continuously as part of traditional Chinese medicine for almost 1700 years. The usual human dose is 9 to 27 grams per day of the raw herb. Ciwujia has been shown to be remarkably safe. It has been administered to laboratory animals in multiple studies, at doses ranging from 60 to 200 times the recommended human dose. Ciwujia does not contain caffeine and does not produce any stimulant or anabolic steroid side effects.

Ciwujia has been used in Traditional Chinese Medicine to treat fatigue and to bolster the immune system. This root intrigued researchers because of published reports on the use of ciwujia by mountain climbers. These reports describe the use of ciwujia to improve work performance at high altitudes and low oxygen conditions. Additional studies showed that laboratory animals administered ciwujia survived longer under low oxygen conditions and that ciwujia could increase oxygenation of heart muscle tissue. Ciwujia is marketed by PacificHealth Laboratories under the trademark of ENDUROX.

1. Effect of ENDUROX on exercise performance during high intensity exercise Eight healthy male adults underwent an aerobic and anaerobic assessment using a stationary bicycle ergometer in which power was increased from 60 to 210 watts at 30-watt intervals. Each interval lasted 3 minutes. Subjects underwent minute-by-minute heart rate reportings. Energy expenditure, oxygen intake, carbon dioxide expiration, and lactic acid were measured at the end of each interval. To assess anaerobic power, subjects started at low resistance that increased to a specified load in 3 to 5 seconds. Subjects continued at their maximum strength for 30 seconds at which the maximum anaerobic power was recorded. Following the initial assessment, each subject was administered 800 mg of ENDUROX daily for 2 weeks. They returned to the exercise physiology laboratory for a repeat of the aerobic and anaerobic assessments.

After the administration of ENDUROX there was a decrease in lactic acid levels that became more pronounced at higher energy loads. At 150 to 180 watts, the decrease in lactic acid levels, when compared to the control group, ranged from 31% to 33%.

During exercise, carbohydrate and fat represent the primary sources of energy. A decline in the respiratory quotient (RQ) indicates that relatively less energy is produced by carbohydrate metabolism and more from fat metabolism. Following administration of ENDUROX, there was a significant drop in the RQ at various energy loads. A decrease in RQ can be translated into a percentage increase in fat metabolism.

Mean increase in fat utilization in the ENDUROX group over the study was 43.2%. These results indicate that ENDUROX offers significant advantages during exercise. By shifting the energy source from carbohydrate to fat during exercise, ENDUROX increases fat metabolism and delays the buildup of lactic acid*. (patent approved)

The mean heart rate recovery of the ENDUROX group compared to the control group. Zero time was the heart rate at the end of the anaerobic assessment. Fifteen minutes following cessation of exercise the mean heart rate in the ENDUROX group was 113% of the pre-exercise value versus 135% in the control group.

The anaerobic threshold was computed by plotting lactic acid levels versus power load for each group. The ENDUROX group demonstrated a 12.4% increase in the anaerobic threshold over the control group.

2. Effect of ENDUROX on exercise performance on a treadmill during low-intensity, long duration exercise To determine if ENDUROX would have a similar effect in individuals performing low-intensity exercise, a second trial was conducted in the exercise physiology laboratory at the University of North Texas Health Science Center.

Sixteen subjects, eight in the control group and eight in the ENDUROX group (1200 mg/day for 2 weeks), underwent a 10-minute exercise on the treadmill at 3.5 mph. Oxygen consumption, carbon dioxide expiration, and RQ were measured continuously. When compared to control there was a decrease in RQ which translated into a 22% increase in fat metabolism.

3. Effect of ENDUROX on exercise performance on a stationary bike during low intensity long duration exercise To better understand the effect of ENDUROX on exercise of longer duration, 10 males ranging in age from 18 to 23 underwent aerobic measurements using a Monark power bike. Subjects pedaled under a light workload of 100 watts at a rotational speed of 60 rpms for 60 minutes. Heart rate, oxygen, CO2, and RQ were measured every 4 minutes. After the test was completed, measurements continued for 15 minutes through recovery. The subjects were then administered 800 mg of ENDUROX daily for 10 days and then returned to the laboratory for a second aerobic assessment.

The mean drop in RQ is 0.09, which translates into a 30% increase in fat metabolism.

There was also a statistically significant decrease in heart rate. The mean before-treatment value (control) was 147, compared to 137 after administration of ENDUROX.

Furthermore, oxygen intake per heartbeat increased 4.62%. During recovery, oxygen intake per heartbeat in the ENDUROX group increased 13% over the control group. These results show that ENDUROX increases oxygen intake per heartbeat during exercise and recovery.

Conclusions There has been an increased research focus on identifying agents that could enhance exercise performance. This report summarizes laboratory investigations on a new product, ENDUROX, which has been shown to significantly improve workout performance through a carbohydrate-sparing action. During exercise, ENDUROX shifts the energy source from carbohydrate to fat, thereby increasing fat metabolism up to 43% over control groups. This carbohydrate shift also improves endurance by delaying the lactic acid buildup associated with muscle fatigue. In addition, ENDUROX raises the anaerobic threshold by 12.4% and increases recovery following exercise as measured by heart rate. Previously published studies and a well-documented history of use indicate that ENDUROX has a remarkably good safety profile. ENDUROX appears to be a safe and useful agent for improving exercise performance.