CLA is a mixture of fatty acids that are derivatives of linoleic acid, and is mainly found in meat and dairy food, but can also be found in certain oils including safflower oil. For years CLA has been studied for its anticarcinogenic properties, but recently has received attention for its ability to modify energy and fat metabolism. Recent studies have demonstrated that CLA has the ability to reduce body fat of overweight or obese individuals while maintaining muscle mass.
Ingredients
Content: Conjulite 1000 mg. Polyphenon 60 0.5 mg.
Directions
Suggested Usage: Adults take 2 softgels daily or as directed by physician.
Category: Weight Reduction, Other Natural Lipids Health Function: Weight Reduction
Indications / UsesCLA is a mixture of conjugated dienoic derivatives
of linoleic acid from safflower oil. Conjugated
linoleic acid is found mainly in meat and dairy foods;
however it can also be found in certain vegetable oils.
Its presence in human tissue comes not only from
dietary sources, but also from in vivo oxidation of
linoleic acid. Although CLA’s activity as a potent
metabolic modulator was first recognized in studies
of its anticarcinogenic properties in fried hamburger,
research of its metabolic activity has now expanded
to include its ability to modulate lipid and energy
metabolism, particularly control of body fat and
muscle, as well as atherosclerosis.
Research in several animal models has demonstrated
that CLA reduces body fat accumulation. Some
studies have shown that the reduction in body fat
occurs regardless of whether the diet is high or low in
fat. It appears that increased energy expenditure is
responsible for the decreased fat accumulation.
Researchers have observed an increase in fat
oxidation, but not a decrease in fat biosynthesis.
Mice fed a high fat diet with 1% CLA exhibited a
50% reduction in weights of adipose depots, but no
significant effects on body weight or energy intake.
Energy expenditure persistently increased almost 8%
through the trial period. This chronic increase in
metabolic rate is thought to be responsible for the
reduction in body fat stores.
Uncoupling protein gene expression in the mice’s
brown fat may be partially responsible for this
increased metabolic rate. CLA’s antiobesity effects
have also been suggested to involve an inhibition
and/or apoptosis of (pre)adipocytes.
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